Ms Michelle (Xiaomeng) Xu is a former honours student, now enrolled in the Doctoral Training Program in DDB at MIPS
Publications while in the lab
Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM. Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLoS Biol. 2021 Jun 4;19(6):e3001295. doi: 10.1371/journal.pbio.3001295.
Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Piper NBC, Whitfield EA, Stewart GD, Xu X, Furness SGB. Biochem Pharmacol. 2022 Jun 6;202:115115. doi: 10.1016/j.bcp.2022.115115. Epub ahead of print. PMID: 35671790.
Dr. Anna Malinovitch (nee Ostrovskaya), former PhD student and now a Knowledge and Technology Transfer Associate at the University of Melbourne
Publications while in the lab
Ostrovskaya A, Hick C, Hutchinson DS, Stringer BW, Wookey PJ, Wootten D, Sexton PM, Furness SGB. Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer. 2019 Feb 18;19(1):157.
Ostrovskaya A, Findlay DM, Sexton PM, Furness SGB. Calcitonin. Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier; 2017. 12
Dr. Kavita Pabreja, former PhD student now a research associate at the school of public health at the university of Newcastle
Publications while in the lab
Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM. The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. Cell. 2016 Jun 16;165(7):1632-43. doi:10.1016/j.cell.2016.05.023. PubMed PMID: 27315480; PubMed Central PMCID: PMC4912689.
Pabreja K, Mohd MA, Koole C, Wootten D, Furness SG. Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. Br J Pharmacol. 2014 Mar;171(5):1114-28. doi: 10.1111/bph.12313. PubMed PMID: 23889512.
Koole C, Pabreja K, Savage EE, Wootten D, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochem Soc Trans. 2013 Feb 1;41(1):172-9. doi: 10.1042/BST20120236. Review. PubMed PMID: 23356279.
Dr. Emma DalMaso, former PhD student now a product sales specialist with Cytiva
Publications while in the lab
Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S,Reynolds CA, Ramírez-Aportela E, Carazo J-M, Hick CA, Furness SGB, Hay DL, Liang Y-L, Miller LJ, Christopoulos A, Wang M-W, Wootten D, and Sexton PM. The Molecular Control of Calcitonin Receptor Signaling. ACS Pharmacology & Translational Science. 2019;:acsptsci.8b00056. https://doi.org/10.1021/acsptsci.8b00056
Dal Maso E, Zhu Y, Pham V, Reynolds CA, Deganutti G, Hick CA, Yang D, Christopoulos A, Hay DL, Wang MW, Sexton PM, Furness SGB*, Wootten D*. Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochem Pharmacol. 2018 Apr;150:214-244. doi: 10.1016/j.bcp.2018.02.005. PubMed PMID: 29454620; PubMed Central PMCID: PMC5908784.
Dal Maso E, Just R, Hick C, Christopoulos A, Sexton PM, Wootten D, Furness SGB. Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochem Pharmacol. 2018 Feb;148:111-129. https://doi.org/10.1016/j.bcp.2017.12.016. PubMed PMID: 29277692.
Furness SG, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D, Sexton PM. Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy. Cell. 2016 Oct 20;167(3):739-749.e11. doi: 10.1016/j.cell.2016.09.021. PubMed PMID: 27720449.
Ms. Muzaida Aminah Mohd, former honours student now a Senior Projects Coordinator with Cytopeutics, Malaysia
Publications while in the lab
Pabreja K, Mohd MA, Koole C, Wootten D, Furness SG. Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. Br J Pharmacol. 2014 Mar;171(5):1114-28. doi: 10.1111/bph.12313. PubMed PMID: 23889512.