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Our Work

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2020

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2019

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2018

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2016

Furness SG, Hare DL, Kourakis A, Turnley AM, Wookey PJ. A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death. Cell Death Discov. 2016 Oct 10;2:16062. https://doi.org/10.1038/cddiscovery.2016.62 PubMed PMID: 27777788; PubMed Central PMCID: PMC5056446.

Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopoulos A, Sexton PM (2016). Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochem Pharmacol. Oct 15;118:68-87. doi: 10.1016/j.bcp.2016.08.015. Epub 2016 Aug 26. PubMed PMID: 27569426; PubMed Central PMCID: PMC5063953.

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Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br J Pharmacol. 2015 Jan;172(1):185-200. doi: 10.1111/bph.12937. PubMed PMID: 25220431; PubMed Central PMCID: PMC4280977.

2015

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Andreassen KV, Hjuler ST, Furness SG, Sexton PM, Christopoulos A, Nosjean O, Karsdal MA, Henriksen K. Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS ONE. 2014 Mar 18;9(3):e92042. doi: 10.1371/journal.pone.0092042

2014

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Savage EE, Wootten D, Christopoulos A, Sexton PM, Furness SG. A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. Biotechniques. 2013 Apr;54(4):217-21. doi: 10.2144/000114013. PubMed PMID: 23581469.

2013

Koole C, Pabreja K, Savage EE, Wootten D, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochem Soc Trans. 2013 Feb 1;41(1):172-9. doi: 10.1042/BST20120236. Review. PubMed PMID: 23356279.

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Harikumar KG, Wootten D, Pinon DI, Koole C, Ball AM, Furness SG, Graham B, Dong M, Christopoulos A, Miller LJ, Sexton PM. Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18607-12. doi: 10.1073/pnas.1205227109. PubMed PMID: 23091034; PubMed Central PMCID: PMC3494884.

2012

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Hao N, Lee KL, Furness SG, Bosdotter C, Poellinger L, Whitelaw ML (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Mol Pharmacol. 2012 Dec;82(6):1082-93. doi: 10.1124/mol.112.078873. Aug 30. PubMed PMID: 22936816.

Willard FS, Wootten D, Showalter AD, Savage EE, Ficorilli J, Farb TB, Bokvist K, Alsina-Fernandez J, Furness SG, Christopoulos A, Sexton PM, Sloop KW. Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol Pharmacol. 2012 Dec;82(6):1066-73. doi: 10.1124/mol.112.080432. PubMed PMID: 22930710.

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Wookey PJ, McLean CA, Hwang P, Furness SG, Nguyen S, Kourakis A, Hare DL, Rosenfeld JV. The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology. 2012 May;60(6):895-910. doi: 10.1111/j.1365-2559.2011.04146.x. PubMed PMID: 22335784.

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prior to 2012

Whelan F, Hao N, Furness SG, Whitelaw ML, Chapman-Smith A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Mol Pharmacol. 77(6):1037-46. DOI: 10.1124/mol.109.062927 Epub 2010 Mar 15. PubMed PMID: 20231332.

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Furness SG, Whelan F. (2009) The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacol Ther. 124(3):336-53. DOI: 10.1016/j.pharmthera.2009.09.004 Epub 2009 Sep 23. PubMed PMID: 19781569. 

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Dave KA, Whelan F, Bindloss C, Furness SG, Chapman-Smith A, Whitelaw ML, Gorman JJ. Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Mol Cell Proteomics. 2009 Apr;8(4):706-19. doi: 10.1074/mcp.M800459-MCP200. Epub 2008 Dec 4. PMID: 19059900

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Furness SG & Whelan F. The pleiotropy of dioxin toxicity—xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacol Ther. 2009 Dec;124(3):336-53. doi: 10.1016/j.pharmthera.2009.09.004. PubMed PMID: 19781569.

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Morfis M, Tilakaratne N, Furness S.G., Christopoulos G, Werry T.D., Christopoulos A, Sexton P.M. (2008) Receptor activity modifying proteins differentially modulate the G protein-coupling EFFICIENCY of amylin receptors. Endocrinology. 2008 Jul 3. [Epub ahead of print doi:10.1210/en.2007-1735]

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Furness SGB & McNagny K. (2006) Beyond mere markers – functions for CD34 family sialomucins in hematopoiesis. Immunologic Research. 34:13-34 doi: 10.1385/IR:34:1:13

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Tan PC, Furness SG, Merkens H, Lin S, McCoy ML, Roskelley CD, Kast J, McNagny KM. (2006) NHERF-1 is an hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells. 24, 1150-61. doi: 10.1634/stemcells.2005-0426

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